Abstract
Primordial germ cells (PGC) derive from the epiblast and migrate through the primitive hindgut to reach the gonadal ridges. During this process, PGC undergo an epigenetic reprogramming that is marked by bulk DNA demethylation. This demethylation contributes to the reduction of potential epimutations and to paternal imprinting erasure. The ten-eleven translocation (TET) and thymine-DNA gly…