Abstract
Precocious puberty is defined as the development of sexual characteristics in girls before the age of 8 years. It can be classified as central precocious puberty (CPP) when it is due to the premature activation of the gonadotropic axis and as idiopathic (ICPP), when there is no lesion in the central nervous system. Treatment with gonadotropin-releasing hormone analogs (GnRHa) is the firs…