Abstract
The amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by death of motor neurons in brain and spinal cord, leading to muscular atrophy, paralysis, and death. Importantly, alterations in lipid metabolism due to chronic inflammation and oxidative stress are strongly linked to ALS. The central nervous system (CNS) is enriched in polyunsaturated fatty acids (PUF…