CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto (EERP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor of Pharmacology at the University of São Paulo (Ribeirão Preto College of Nursing - EERP/USP)Industrial Pharmacist, PhD and MsC in PharmacologyWe investigate genetic biomarkers of susceptibility to complex diseases or which predict pharmacological responses of drug therapy, especially those involving cardiovascular and psychiatric diseases (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Depression is a highly prevalent mood disorder and it generates prejudices both to the patient and the society. Most studies focus inflammation, cortisol, neurothrophic factors as the main causes for depression. One common factors between these different mechanisms is a raise in matrix metalloproteinases(MMP), which lead to tissue remodeling, change in the density of synaptic boutons and …
Nitric oxide (NO) is the main factor responsible for vascular relaxation. Reduction of NO production by reduced expression or activity of endothelial nitric oxide synthase (eNOS) or reduced soluble guanylate cyclase (sGC) activity may lead to cardiovascular disease. The NOS3 gene has its expression strongly restricted to vascular endothelial cells through DNA methylation. It has been expe…
Activation of soluble Guanylate Cyclase (sGC) enzyme expressed in bladder, urethra and prostate smooth muscles induces tissue relaxations by elevating cyclic GMP levels. We have shown that sGC enzyme is found in an oxidized/degraded state in Obesity, Aging and Inflammation (cystitis) conditions, hence producing reduced cGMP levels, which may explain the enhanced contractility of the lower…
Genetics of complex diseases and drug responses are the main targets of Pharmacogenetics. The idea is to try to determine the chances of a given person to develop a disease or not respond to common pharmacological treatments. Regarding erectile dysfunction, it has already been shown a close relationship between this disease, cardiovascular risk, and future cardiovascular-related death. Th…
It is recent the knowledge that epigenetic reprogramming can occur in adulthood, impacting the course of certain diseases. Key genes play an essential role in the functioning and maintenance of the cardiovascular system, since the deletion of some of them, such as NOS3, which expresses the endothelial Nitric Oxide Synthase (eNOS) gene, responsible for synthesizing most of the Nitric Oxide…
Nitric oxide (NO) is a potent vasodilator, being responsible for maintaining a healthy vascular endothelium. Nitric oxide synthases (NOS) of the endothelial type (eNOS - NOSIII) control blood pressure and elicit protecting effects on vessels. Statins cause effects that go beyond the classical mechanism (pleiotropic effects), among them increasing the expression of eNOS and consequently in…
Aging is a major risk factor for the development of severe acute respiratory distress syndrome (ARDS) in patients fighting both viral and bacterial respiratory infection. In ARDS, dysfunctional and inflamed pulmonary vasculature promotes severe lung edema and reduces oxygen concentration, ultimately leading to premature death of the patients. Multiple studies have shown that lost or dysfu…
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 3 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 8 / 7 | All research grants and scholarships |
| Associated processes | |