Abstract
The splicing factor SF1 recognizes the 3 'regions of the introns during the early stages of spliceosome formation, but is not required for general splicing of all pre-mRNA in eukaryotic cells. Thus, SF1 targets a subset of pre-mRNAs, acting as an alternative splicing factor. Besides SF1 function in splicing, its role in tumorigenesis has also been described. SF1 can act either as an oncog…