CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Colômbia
PhD in Biological Sciences (Molecular Biology/Biochemistry, Universidade Federal de São Paulo UNIFESP, São Paulo, SP, Brazil & Instituto Cajal-CSIC, Madrid, Spain) with research experience in the study of cellular and molecular bases of nervous system development and regeneration. In addition, I am interested in the development and application of in vitro methods for the study of glial and neuronal biology within a translational focus. (Source: Lattes Curriculum)
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The Neurovascular Unit (NVU) is a multicellular structure whose primary function is the regulation of vascular permeability and blood flow, allowing the supply of oxygen and glucose for the functioning of the neural network. Traumatic brain injury (TBI) compromises the integrity of the NVU and causes a rupture in the neuron-astrocyte-vasculature communication, causing the dysfunction of t…
Astrocyte activation is the main line of response to lesions in the central nervous system (CNS). The reactive astrocytes perform different roles, as the maintenance of the inflammatory response and secretion of factors that modify the extracellular matrix at the injury site. Recent studies show that reactive astrocytes undergo a process of dedifferentiation into neural stem cells (NSC). …
The neurovascular unit (NVU) is a complex, dynamic structure made up of neurons, glia, and vascular cells. Recent data revealed how glia interactions might be fundamental for NVU function. Despite the vast knowledge of glia biology, some fundamental aspects remain unknown. For instance, the exact physiological implications of different glial lineages in neuron-glial networks and their con…
Astrocytes are the first line of cellular response after a brain injury. To fulfil this role, astrocytes undergo a wide variety of alterations in gene expression and phenotype. Increasing evidence indicates that neurogenesis may have a regenerative role in response to brain injury and disease. Moreover, it has been suggested that, activation of signaling mechanisms regulating adult neural…
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