Abstract
Mucins are highly glycosylated O-glycoproteins that contain repeated motifs in typical tandem, rich is serine (Ser) and threonine (Thr), which represent potential sites for abundant glycosylation. ±-Dystroglycan (±-DG) mucins contain the tetrasaccharidic structural motif Neu5Ac±2-3Gal²1-4GlcNAc²1-2Man±-O-Ser/Thr biosynthesized by specific glycosyltransferases enzymes. Thus, mutations in s…