Abstract
Toll like receptor 4 (TLR4) has a significant role in innate immunity. Right after activation, TLR4 signals through MyD88 pathway, producing a pro-inflammatory response and cell proliferation. This signal pathway induces NF-kB translocation to the nucleus and cytokine production. TLR4 is also internalized to the endosome and signals through TRIF, producing an anti-inflammatory response an…