Abstract
Sickle cell anemia (SCA) occurs due to molecular changes in the beta globin gene. A point mutation results in the substitution of one base, where an adenine is substituted by a thymine. This leads to the production of an abnormal hemoglobin - HbS. The pathophysiology of this disease causes, primarily, the polymerization of HbS and subsequent sickling of red blood cells, causing shortening…