Abstract
Loxoscelism is considered of great importance in public health for the high rate of reported cases of envenoming and more than 5,000 accidents are reported per year. The Loxosceles venom is a complex protein mixture. Studies have shown that the sphingomyelinase D (SMase D) is the main component of the venom, responsible for local and systemic manifestations by Loxosceles spider envenoming…