Abstract
Little is known about the kinase ATR role in the homeostasis of the genome of primitive eukaryotes, such as trypanosomatids. In other eukaryotes, ATR participates in the signaling of DNA damaged structures, mainly through the phosphorylation of Chk1 and subsequent cell cycle arrest. The main objective of this project is to investigate the conservation of ATR kinase in Leishmania and explo…