Abstract
Xeroderma pigmentosum (XP) is an inherited autosomal recessive syndrome with a 1,000 fold elevated skin cancer rate in areas exposed to UV light. XP is caused by mutations in one of seven genes (XPA-XPG) of nucleotide excision repair (NER) pathway or in one translesion DNA polymerase (POLH). The XPC protein is a lesion recognition factor in NER, but it has also been shown to interact and …