CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biomedical Sciences by Universidade Federal de São Paulo (EPM/UNIFESP) - 2019. PhD Student in the Department of Microbiology and Immunology at EPM/UNIFESP, focusing on the following topics: B-1 cell precursor, aging and hyperproliferative diseases. (Source: Lattes Curriculum)
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Accumulation of mutations and changes in the immune system could happen in aging, for example, due to environmental pressures. It was seen that there is an accumulation of B-1 cells in bone marrow and lymphoid organs of old mice and our group showed that the B-1 cell progenitor (B-1p - Lin-CD45R-CD19+CD93+) population increases in the bone marrow of healthy old C57Bl/6 mice (with 30 weeks…
Hyperproliferative diseases, such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are possibly related to some disturb in the apoptosis pathway, specifically in B-1a cells (CD5+). These problems result in the accumulation of B-1a cells in lymphoid organs, bone marrow or periphery, as observed in experimental models with old animals. Furthermore, it is known th…
B cell development represents a very orchestrated pathway that initiates with hematopoietic stem cells resulting in mature B lymphocytes, which will participate in immunological responses. The genetic program for this lymphopoiesis differs between fetal and adult human samples and is regulated by several molecules, including microRNAs. The axis formed by the microRNA Let7 and its regulato…
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