, acting on the following subjects: endotoxina, resistência à leptina, inflamação, microglia and lps. (Source: Lattes Curriculum)
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Phosphodiesterase 4 (PDE4) is an enzyme that hydrolyzes cAMP (cyclic adenosine monophosphate), reducing intracellular cAMP concentrations. It was recently shown that PDE4 knockout mouse is resistant to diet-induced obesity. Additionally, preliminary data from this study demonstrated that PDE4 inhibition with rolipram reduces food intake and adiposity, which is associated with an energy ex…
It is well known that obesity is related to chronic low-grade inflammation and an increase in pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF). The inhibition of Phosphodiesterase 4 (PDE4) can strongly inhibit the release of TNF and reduce inflammation after LPS challenge. Additionally, it was shown that PDE4 -/- mouse is resistant to diet-induced obesity. This study a…
Lipopolyssaccharyde (LPS) is a cell-wall component of gram negative bacteria which acts as an activator of immune responses and is widely used in models that mimic inflammation. During acute endotoxemia it is possible to notice LPS induced hypophagia, however, in chronic endotoxemia this effect is ablated due to resistance to endotoxin effects. Additionally, animals receiving multiple LPS…
Non-alcoholic fatty liver disease is characterized by the pathological increase of lipid droplets and its decreased utilization in hepatocytes. In addition, this condition is associated with increased sympathetic nervous system imbalance, which is reversed by anti-inflammatory approaches. The inhibition of Phosphodiesterase 4 (PDE4) can strongly inhibit the release of TNF-alpha and reduce…
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CV Lattes
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