Abstract
Angiotensin II, a hypertensive peptide, and bradykinin, a hipotensive peptide, are crucial humoral factors for blood pressure regulation. The key enzyme for this system is angiotensin-converting enzyme (ACE) that produces angiotensin II from angiotensin I and degrades bradykinin. The discovery of the first natural inhibitors for this enzyme, the bradykinin potentiating peptides (BPPs), ma…