Abstract
Insulin-like growth factor (IGF) along with its binding protein (IGFBP), participates in lipid metabolism and adiposity regulation. A good regulator for this group is Pregnancy-Associated Plasma Protein-A (PAPP-A), which is capable of breaking the bonds between IGF and its binding proteins, while increasing the bioavailability of free IGF, leading to a reduction in the amount of lipids du…