Abstract
Breast cancer is the more frequent tumor type in women, about 5-10% of the cases are hereditary. The main genes associated with a higher breast cancer predisposition are BRCA1, BRCA2, TP53, PTEN, CDH1, STK11 and, more recently, PALB2, a tumor suppressor gene involved in several cellular functions, mainly in the DNA Double-Strand Break (DSB) repair. The genetic variants found in these gene…