Abstract
Astrocytomas are aggressive tumors from the central nervous system (CNS) developing from astrocytes. The most common and fatal subtype is the Glioblastoma Multiforme (GBM, grade IV, WHO). High-grade astrocytomas (grades III and IV) exhibit a so-called "infiltrative growth" pattern of brain spreading, which emerges as a combination of uncontrolled cell proliferation and intense parenchymal…