Abstract
Central Precocious puberty (CPP) is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Most of CPP cases affect girls and keep idiopathic. Genetic alterations associated to CPP was first describe in kisspeptin system genes (KISS1 and KISS1R) Loss-of-function mutations in imprinted MKRN3 gene is describing to be…