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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Biological Sciences, Ph.D. in Biochemistry and Molecular Biology at University of São Paulo, SP, Brazil. Post-Doc at Columbia University (1993). Ex-Director of the Biotechnology Center of Instituto Butantan (2002-2010). Ex-Director of the Technological Development and Production Division of Instituto Butantan (2012-2016). Ex-Member of the CNTBio (Technical National Comission for Biosecurity) (2012-2016). Academic Editor of PLoS One (from 2008 up to now). More than 160 articles indexed at ISI, h-index 41 and some patents applied in Brazil and in other countries. Some awards, including the Medal of Science and Technology Merit from the São Paulo State Govern, Medal of Excellence in Pharmaceutical Development by the National Academy of Pharmaceutical Sciences (2016), Alba Lavras Medal from the Sao Paulo State Scientific Researchers Association (2016), Senior Researcher Award by Biotech Space (2017). Scientific contributions in the field of vaccine development, biotechnology, genomic, toxinology, molecular and cell biology. Fellow 1C from CNPq. (Source: Lattes Curriculum)
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Butantan Institute is nowadays the main producer of Influenza vaccine in the Southern Hemisphere, with the challenge of achieving national autonomy by increasing the capacity of production of the Flu vaccine. Therefore, influenza vaccines in development such as the quadrivalent seasonal, adjuvanted formulations, high dose and pre-pandemic H5Nx vaccines are under assessement. Not only Infl…
Instituto Butantan (IB), has always worked to answer public health challenges and has a long tradition in the development and manufacturing of vaccines and antibodies. This project addresses both areas, influenza vaccines and human monoclonal antibodies, focusing on critical targets that demand attention and require the use of strategies based on solid scientific, clinical, regulatory and…
The production of recombinant therapeutical proteins represents one of the most productive industries in the area of molecular medicine nowadays, comprising complex molecules of high value. These proteins normally present a glycosylation pattern proper of humans, having great importance in protein folding, stability and biological activity. Seeking to reproduce the human glycosylation pat…
We are forwarding to FAPESP the Thematic project which aims to contribute to knowledge of the host-pathogen relationship biology and evasion mechanisms of the spirochete Leptospira combining genomic information and experimental studies. The results to be obtained should/can be used for the purpose of developing new forms of intervention of the disease caused by this microorganism, mainly…
Leptospirosis is considered the most widespread zoonotic disease caused by the spirochaete from the Leptospira genus. Tn Brazil, 80% of all the diagnosed cases are due to Leptospira interrogans serovar Copenhageni. Rats are the main reservoir in urban centers and the bacteria are disseminated through animal urines. Around 10,000 cases of leptospirosis are annually notified to FUNASA (Heal…
(Only some records are available in English at this moment)
Epidemiological data indicate that approximately 1 billion people are infected withinfluenza viruses annually, of which 3 to 5 million can progress to more severe casesresulting in thousands of deaths a year. Vaccines have been the allied tool to mitigatethe spread of the virus, because they act prophylactically in populations, besides helpingto contain the emergence of new viruses. Howev…
The production of recombinant proteins is a recorrent approach for comercials and farmaceutic purposes. Among the heterologous systems, the yeast Pichia pastoris is one of the most explored systems because of its high production, beeing a advantageous choice for the proejct. The deposition disease studied in the research, Gauchers disease, occurs because of the absense or deficiency of th…
Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of the genus Leptospira which colonize the renal tubules of wild or domestic animals and are released to the external environment in urine. The transmission occurs through accidental contact with water, food and soil contaminated with urine of infected animals. The development of a vaccine is very important, since the co…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 14 / 5 | Completed research grants |
| 46 / 11 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 63 / 18 | All research grants and scholarships |
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