CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor of Dentistry, Masters of Science - Pharmacology, PhD Candidate in Science - Pharmacology. (Source: Lattes Curriculum)
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Chronic pain represents a global burden and many attempts to elucidate its underlying mechanisms have been made to develop efficacious therapies. Experimental models of neuropathic chronic pain such as peripheral nerve lesion and paclitaxel-induced peripheral neuropathic pain generate cellular stress in neurons, increasing local metabolism, and possibly leading to metabolites accumulation…
Paclitaxel is a chemotherapeutic agent widely employed in the treatment of solid tumors, but the ensuing peripheral neuropathy is a dose-limiting side-effect and a common cause of treatment interruption. Paradoxically, neurons are susceptible to paclitaxel albeit they are not dividing cells. Axonal degeneration and demyelination correlate with clinical symptoms that persist well beyond tr…
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, FRANCISCO ISAAC F.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. Peripheral nitric oxide signaling directly blocks inflammatory pain. Biochemical Pharmacology, v. 176, n. SI, JUN 2020. Web of Science Citations: 0. (13/08216-2, 19/14285-3)