Abstract
In vivo administration of dimethyl fumarate (DMF) significantly reduces the severity of autoimmune experimental encephalomyelitis (EAE). Recent studies have shown that reducing the severity of EAE by treatment with DMF is due to the fact that monomethil fumarate (MMF) reduces the production of proinflammatory cytokines by the stimulation of HCAR2 receptor present in dendritic cells. Since…