Abstract
Glioblastoma Multiforme (GBM) is a highly aggressive glial tumor, with a high recurrence and death rates. Recent studies indicate that the GBM is maintained by a subpopulation of cellswith stem-cell characteristics, denominated Glioblastoma Stem Cells (GSCs). Recently ourgroup has identified the Cellular Prion Protein as having an important role in the modulationof the GSCs undifferentiat…