Abstract
Prostacyclin (PGI2) is produced in vascular endothelial cells and acts by IP prostacyclin receptor activation to cause vasodilation and inhibit smooth muscle cell proliferation and platelet aggregation. In addition to nitric oxide (NO), prostanoids play an important role on the vascular tone control. Prostanoids are produced by COX isoforms that metabolize arachidonic acid to PGG2 and PGH…