Abstract
Congenital hypopituitarism is a multiple hormonal deficiency due to mutations in transcription factors involved in pituitary embryogenesis. In humans, mutations in PROP1 gene are the most common cause of congenital hypopituitarism, that manifests by deficits of growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), gonadotropins (FSH and LH), and a variable and progressi…