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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Nilmar Silvio Moretti in research grants and scholarships supported by FAPESP.
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Leishmania infantum is a parasite that causes visceral leishmaniasis, which if not treated can be lethal. During the sandfly bloodmeal the parasite can ben inoculated, reach the bloodstream and infect liver and spleen resident macrophages, which during the progression of infection can lead to the development of hepato and splenomegaly. Understanding the L. infantum host interaction in the…
The life cycle of species of the genus Leishmania is complex and involves flagellated promastigote forms present in the sandfly vector and amastigote forms present inside the macrophages of the mammalian host. During the transition from one host to another, the parasite encounters different environmental conditions that lead to changes in its gene expression, protein synthesis, metabolism…
The study of protein acetylation in different organisms has shown that this post-translational modification is present in proteins involved in several cellular processes. Recently, we characterize the acetyloma of the epimastigote form of Trypanosoma cruzi and the procyclic and bloodstream forms of Trypanosoma brucei. We have verified that these forms have a very different protein acetyla…
Eukaryotic cells use post-translational modifications such as lysine acetylation to regulate gene expression and immune response, playing a crucial role in cellular homeostasis. Leishmania spp. infection induces a change in macrophage polarization,favoring a phenotype that compromises the immune response, resulting in decreased production of pro-inflammatory cytokines and microbicidal cap…
The life cycle of Leishmania involves promastigotes in the insect vector and amastigotes in the mammalian host. Adaptation to these distinct environments requires not only morphological changes but also alterations in translation and gene expression. In Leishmania, gene expression is predominantly regulated at the post-transcriptional level through mechanisms involving mRNA stability and …
Leishmaniasis is a group of neglected tropical diseases caused by protozoan parasites of the genus Leishmania, with more than 20 species capable of infecting humans. During its life cycle, the parasite alternates between an invertebrate host, where it exists in the promastigote form, and a vertebrate host, where it resides as intracellular amastigotes within macrophages. In the intracellu…
(Only some records are available in English at this moment)
The life cycle of species of the genus Leishmania is complex and involves flagellated promastigotes present in the sandfly insect vector and amastigotes present within the macrophages of the mammalian host. Leishmania has developed different host cell subversion mechanisms, ranging from changes in the expression of specific genes to changes in metabolism, such as glycolysis, ensuring its …
Leishmania spp. is the etiological agent of leishmaniasis, a group of diseases that can manifest in three main forms: cutaneous, mucocutaneous and visceral. During its life cycle Leishmania spp. circulates between two hosts, one invertebrate and one vertebrate, and during the transition between both it needs to adapt to the environmental changes found, and for that, the parasite uses chan…
Leishmania spp. it is the etiological agent of leishmaniasis, a group of diseases that can manifest in three main forms: cutaneous, mucocutaneous and visceral. The diversity of clinical cases presented varies according to the species of Leishmania, with more than 20 species that can affect humans being described. During its life cycle Leishmania spp. circulates between an invertebrate and…
(Only some records are available in English at this moment)
Leishmania is the etiologic agent of Leishmaniasis, a serious infectious disease, that can manifest itself in three main forms: cutaneous, mucocutaneous and visceral. During its life cycle, the parasite faces different environments and adapting to these conditions changes gene expression, translation and metabolism. Protein acetylation is regulated by two families of enzymes, lysine acety…
Leishmania spp. causes leishmaniases, and during its life cycle, the parasite shifts between two hosts and needs to adapt to various environmental conditions to survive. This adaptation could involve changes in gene expression and translation, which are regulated by chromatin structure modifications and post-transcriptional mechanisms. Recently, it was observed that mRNAs can be modified …
Leishmania species have a complex life cycle involving migrating from an invertebrate to a vertebrate host, placing the parasite in adverse environmental conditions requiring rapid survival adaptation. Another scenario that requires the parasite to adapt is during stress caused by treatment drugs. To overcome these situations the parasite can use different mechanisms that involve for exam…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 9 / 7 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 23 / 21 | All research grants and scholarships |
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