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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Nilmar Silvio Moretti in research grants and scholarships supported by FAPESP.
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Visceral leishmaniasis (VL), caused by Leishmania infantum, is a severe systemic disease that poses a significant public health challenge. In the mammalian host, the parasite invades vital organs such as the spleen and liver, and current therapeutic options are limited. Resistance to pentavalent antimonials, one of the primary choise for treatment, is increasingly compromised by the emerg…
The life cycle of species of the genus Leishmania is complex and involves flagellated promastigote forms present in the sandfly vector and amastigote forms present inside the macrophages of the mammalian host. During the transition from one host to another, the parasite encounters different environmental conditions that lead to changes in its gene expression, protein synthesis, metabolism…
Leishmania infantum is a parasite that causes visceral leishmaniasis, which if not treated can be lethal. During the sandfly bloodmeal the parasite can ben inoculated, reach the bloodstream and infect liver and spleen resident macrophages, which during the progression of infection can lead to the development of hepato and splenomegaly. Understanding the L. infantum host interaction in the…
The study of protein acetylation in different organisms has shown that this post-translational modification is present in proteins involved in several cellular processes. Recently, we characterize the acetyloma of the epimastigote form of Trypanosoma cruzi and the procyclic and bloodstream forms of Trypanosoma brucei. We have verified that these forms have a very different protein acetyla…
Visceral leishmaniasis is a hard handling neglected disease, caused in Brazil by the parasite Leishmania infantum, capable of presenting high mortality rates if not taken care correctly. The treatment involves the utilization of antimonials (Sb), but has been facing problems, especially, due to the rise of resistant strains. The gene expression regulation via epitranscriptomics mechanisms…
Visceral Leishmaniasis (VL), whose etiologic agent in Brazil is the protozoan Leishmania infantum, represents a severe public health problem, presenting high lethality rates when untreated. Conventional treatment is primarily based on the administration of pentavalent antimonials (Sb). However, the efficacy of this therapy has been severely compromised by the emergence of therapeutic fail…
Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania, transmitted by sandflies and responsible for a significant impact on public health in endemic regions. The parasite has a heteroxenous life cycle, characterized by alternating between different environments in the insect vector and the mammalian host, which requires high adaptive plasticity, supporte…
(Only some records are available in English at this moment)
Leishmania sp. is the etiological agent of leishmaniasis, a disease that affects both humans and animals present in various countries. The parasite has a heteroxenous life cycle, as it migrates between its invertebrate vector and a vertebrate host. In this process, it survives under distinct environmental conditions, necessitating changes in its cellular processes, such as gene expression…
The life cycle of species of the genus Leishmania is complex and involves flagellated promastigotes present in the sandfly insect vector and amastigotes present within the macrophages of the mammalian host. Leishmania has developed different host cell subversion mechanisms, ranging from changes in the expression of specific genes to changes in metabolism, such as glycolysis, ensuring its …
Leishmania spp. is the etiological agent of leishmaniasis, a group of diseases that can manifest in three main forms: cutaneous, mucocutaneous and visceral. During its life cycle Leishmania spp. circulates between two hosts, one invertebrate and one vertebrate, and during the transition between both it needs to adapt to the environmental changes found, and for that, the parasite uses chan…
(Only some records are available in English at this moment)
Leishmania is the etiologic agent of Leishmaniasis, a serious infectious disease, that can manifest itself in three main forms: cutaneous, mucocutaneous and visceral. During its life cycle, the parasite faces different environments and adapting to these conditions changes gene expression, translation and metabolism. Protein acetylation is regulated by two families of enzymes, lysine acety…
Leishmania spp. causes leishmaniases, and during its life cycle, the parasite shifts between two hosts and needs to adapt to various environmental conditions to survive. This adaptation could involve changes in gene expression and translation, which are regulated by chromatin structure modifications and post-transcriptional mechanisms. Recently, it was observed that mRNAs can be modified …
Leishmania species have a complex life cycle involving migrating from an invertebrate to a vertebrate host, placing the parasite in adverse environmental conditions requiring rapid survival adaptation. Another scenario that requires the parasite to adapt is during stress caused by treatment drugs. To overcome these situations the parasite can use different mechanisms that involve for exam…
(Only some records are available in English at this moment)