CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas-Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (2005) and master's at Programa de Pós-Graduação em Ciências from Universidade de São Paulo (2008). (Source: Lattes Curriculum)
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Chagas Disease is caused by the protozoan parasite Trypanosoma cruzi which has the same drug of treatment since 1970, benznidazole. The lack of new drugs of treatment reflects the complexity of this parasite biology that is found in four distinct life forms with differences regarding their metabolism and replicative capacity. Infective forms are unable to replicate and this changes among …
Trypanosoma cruzi is the causative agent of Chagas disease, endemic to Latin America and a public health problem in Brazil. This disease still depends on treatment by the same drugs as in the 1970s, and the search for new drugs is a challenge due to the resistance of T. cruzi to treatments. During its complex life cycle, T. cruzi transitions between the insect vector and the mammalian hos…
Chagas disease is caused by Trypanosoma cruzi, an important endemic disease in tropical countries which has been considered a neglected disease by the World Health Organization (WHO). Thus, the study and understanding of this parasite are fundamental to develop new and better treatments. Gene editing by CRISPR/Cas9 together with drug resistance gene insertion has been widely used as a met…
CRISPR/Cas9 technology has been widely used as a very versatile and efficient method of genetic manipulation and is a very promising technique to be applied for studies in T. cruzi. Raising antibodies against specific proteins is time consuming and not always successful, the ability to tag a specific gene locus could facilitate the characterization of many proteins in this parasite. So fa…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 2 / 0 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 6 / 4 | All research grants and scholarships |
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(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 26 |
| Cit./Article | 13.0 |
| Data from Web of Science | |
DE ARAUJO, CHRISTIANE BEZERRA; DE LIMA, LOYZE PAOLA; CALDERANO, SIMONE GUEDES; DAMASCENO, FLAVIA SILVA; SILBER, ARIEL M.; ELIAS, MARIA CAROLINA. Pep5, a Fragment of Cyclin D2, Shows Antiparasitic Effects in Different Stages of the Trypanosoma cruzi Life Cycle and Blocks Parasite Infectivity. Antimicrobial Agents and Chemotherapy, v. 63, n. 5, MAY 2019. Web of Science Citations: 2. (16/50050-2, 16/06034-2, 14/13375-5, 13/07467-1, 17/16553-0)
CALDERANO, SIMONE GUEDES; DROSOPOULOS, WILLIAM C.; QUARESMA, MARINA MONACO; MARQUES, CATARINA A.; KOSIYATRAKUL, SETTAPONG; MCCULLOCH, RICHARD; SCHILDKRAUT, CARL L.; ELIAS, MARIA CAROLINA. Single molecule analysis of Trypanosoma brucei DNA replication dynamics. Nucleic Acids Research, v. 43, n. 5, p. 2655-2665, MAR 11 2015. Web of Science Citations: 13. (11/21570-4, 13/07467-1, 12/24554-2)
CALDERANO, SIMONE GUEDES; NISHIYAMA JUNIOR, MILTON YUTAKA; MARINI, MARJORIE; NUNES, NATHAN DE OLIVEIRA; REIS, MARCELO DA SILVA; PATANE, JOSE SALVATORE LEISTER; DA SILVEIRA, JOSE FRANCO; DA CUNHA, JULIA PINHEIRO CHAGAS; ELIAS, MARIA CAROLINA. Identification of Novel Interspersed DNA Repetitive Elements in the Trypanosoma cruzi Genome Associated with the 3 ` UTRs of Surface Multigenic Families. GENES, v. 11, n. 10, OCT 2020. Web of Science Citations: 0. (16/50050-2, 13/07467-1)
PAVANI, RAPHAEL S.; DE LIMA, LOYZE P.; LIMA, ANDRE A.; FERNANDES, CARLOS A. H.; FRAGOSO, STENIO P.; CALDERANO, SIMONE G.; ELIAS, MARIA CAROLINA. Nuclear export of replication protein A in the nonreplicative infective forms of Trypanosoma cruzi. FEBS Letters, v. 594, n. 10, MAR 2020. Web of Science Citations: 0. (18/21785-0, 13/07467-1, 18/14432-3, 16/50050-2, 14/02978-0)
COSTA, FERNANDA CRISTINA; FRANCISCO, AMANDA FORTES; JAYAWARDHANA, SHIROMANI; CALDERANO, SIMONE GUEDES; LEWIS, MICHAEL D.; OLMO, FRANCISCO; BENEKE, TOM; GLUENZ, EVA; SUNTER, JACK; DEAN, SAMUEL; et al. Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. PLoS Neglected Tropical Diseases, v. 12, n. 4, APR 2018. Web of Science Citations: 13. (16/21283-9, 13/07600-3, 16/08958-7)