CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas-Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (2005) and master's at Programa de Pós-Graduação em Ciências from Universidade de São Paulo (2008). (Source: Lattes Curriculum)
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Trypanosoma cruzi is the causative agent of Chagas disease, identified in 1909 by Carlos Ribeiro Justiniano das Chagas, and remains a public health concern in Brazil to this day. Classified as a neglected disease by the World Health Organization, its treatment is limited to two drugs, benznidazole and nifurtimox, which were introduced in the 1960s. These drugs, however, cause severe side …
Chagas Disease is caused by the protozoan parasite Trypanosoma cruzi which has the same drug of treatment since 1970, benznidazole. The lack of new drugs of treatment reflects the complexity of this parasite biology that is found in four distinct life forms with differences regarding their metabolism and replicative capacity. Infective forms are unable to replicate and this changes among …
CDKs (cyclin dependent kinases) are kinases that work together with cyclins to regulate the cell cycle in model eukaryotes. Through the action of these kinases, cells can progress through the cell cycle or enter quiescence, depending on the nutritional conditions of the environment and the presence of mitogenic stimuli. The entry into quiescence is important for cell survival under unfavo…
Trypanosoma cruzi is a clinically relevant protozoan, causative agent of Chagas disease. Its endemic characteristic to emergent countries is an important contextualization to understand why it still is, proportionally to other model eukaryotes, very little understood. During its life cycle, T. cruzi transit between an invertebrate vector and a mammalian host and in these environments it p…
Trypanosoma cruzi is the causative agent of Chagas disease, endemic to Latin America and a public health problem in Brazil. This disease still depends on treatment with the same drugs as in the 1970s, and the search for new drugs is a challenge due to the resistance and persistence of T. cruzi to treatments. During its complex life cycle, T. cruzi transits between the insect vector and th…
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CRISPR/Cas9 technology has been widely used as a very versatile and efficient method of genetic manipulation and is a very promising technique to be applied for studies in T. cruzi. Raising antibodies against specific proteins is time consuming and not always successful, the ability to tag a specific gene locus could facilitate the characterization of many proteins in this parasite. So fa…
| 1 / 1 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 9 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 10 | All research grants and scholarships |
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