Abstract
The induced pluripotent stem cells (iPSCs) emerged as new biotechnology in 2006 when Takahashi and Yamanaka reprogrammed murine fibroblasts using only the expression of four exogenous factors: Oct4, Sox2, Klf-4 and c-Myc (OSKM). Since then, several reprogramming methodologies for the generation of iPSCs have been developed, especially in non-integrative systems for clinical application to…