Abstract
Chronic lymphatic leukemia (CLL) is a hematopoietic hyperproliferative disease caused by deregulated B-1 cells (CD5+) expansion. Our group demonstrated that CLL cells show dysfunction and altered localization of Ikaros. This protein acts by repressing or activating the gene expression. Ikaros is associated to a protein complex that is able to remodel the chromatin. The major complex that …