CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Bacharelado e Licenciatura em Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (2000) and doctorate at Cancerology from Fundação Antônio Prudente (2008). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: câncer de mama, splicing alternativo, microarray, rt-pcr em tempo real and fitoterapia. (Source: Lattes Curriculum)
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Cancer stem-cells (CSCs) are undifferentiated cells present in heterogeneous tumors, that contribute for the maintenance of cancer through the ability to self-renew and promote tumor repopulation. CSCs do not respond to conventional treatments such as chemo and radiotherapy, that destroy highly proliferative cells and require oxygen to work. Therefore, CSCs survive quiescently, and under …
Cancer stem-cells (CSCs) are undifferentiated cells present in heterogeneous tumors, that contribute for the maintenance of cancer through the ability to self-renew and promote tumor repopulation. CSCs do not respond to conventional treatments such as chemo and radiotherapy, that destroy highly proliferative cells and require oxygen to work. Therefore, CSCs survive quiescently, and under …
In this master's project, we will investigate new approaches for the control and destruction of the undifferentiated cancer stem cell population (CSCs) in the treatment of the most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC). TNBC expresses neither estrogen (ER) and progesterone (PR) hormone receptors nor shows increased expression or amplification of epiderm…
Triple-negative Breast Cancer (TNBC) refers to a cluster of highly heterogeneous diseases that lack hormonal (progesterone and estrogen) receptors, as well as HER2 protein expression/amplification. In addition, this molecular breast cancer subtype has a considerable amount of a functionally heterogeneous subpopulation of cells capable of self-renewal, differentiate and initiate tumors. Th…
Transgenic mice overexpressing Notch4 intracellular domain (Int3) in the mammary gland under the control of the WAP (whey acidic protein) promoter do not lactate and rapidly develop mammary hyperplasias and undifferentiated mammary adenocarcinomas. Considering that the embryonic gene Cripto-1 facilitates the proteolytic intracellular processing of Notch receptors, we sought to investigate…
| 1 / 1 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 3 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 7 / 6 | All research grants and scholarships |
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