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Sensitization of triple-negative breast cancer to chemotherapy by the inhibition cancer stem cells self-renewal

Grant number: 20/04007-3
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2020
Effective date (End): March 31, 2022
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Maria Cristina Rodrigues Rangel
Grantee:Leandro de Lima Coutinho
Home Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:18/08107-2 - Targenting stemness as a strategy for treating triple-negative breast cancer, AP.JP

Abstract

In this master's project, we will investigate new approaches for the control and destruction of the undifferentiated cancer stem cell population (CSCs) in the treatment of the most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC). TNBC expresses neither estrogen (ER) and progesterone (PR) hormone receptors nor shows increased expression or amplification of epidermal growth factor 2 (HER2). In the absence of these markers, there are still no well-defined markers in the clinic that enable the use of target-directed therapies in TNBC. Thus, in this study we will establish complementary strategies to the treatment of TNBC that does not exclude the use of conventional therapies but enhance their action through the negative modulation of the population of CSCs, making resistant tumours more sensitive and responsive to treatments, and preventing their recurrence. (AU)