| Grant number: | 20/04007-3 |
| Support type: | Scholarships in Brazil - Master |
| Effective date (Start): | April 01, 2020 |
| Effective date (End): | March 31, 2022 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Maria Cristina Rodrigues Rangel |
| Grantee: | Leandro de Lima Coutinho |
| Home Institution: | Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated research grant: | 18/08107-2 - Targenting stemness as a strategy for treating triple-negative breast cancer, AP.JP |
Abstract In this master's project, we will investigate new approaches for the control and destruction of the undifferentiated cancer stem cell population (CSCs) in the treatment of the most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC). TNBC expresses neither estrogen (ER) and progesterone (PR) hormone receptors nor shows increased expression or amplification of epidermal growth factor 2 (HER2). In the absence of these markers, there are still no well-defined markers in the clinic that enable the use of target-directed therapies in TNBC. Thus, in this study we will establish complementary strategies to the treatment of TNBC that does not exclude the use of conventional therapies but enhance their action through the negative modulation of the population of CSCs, making resistant tumours more sensitive and responsive to treatments, and preventing their recurrence. (AU) | |