Sensitization of triple-negative breast cancer to chemotherapy by the inhibition cancer stem cells self-renewal

• Grant number: 20/04007-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2020
• End date: December 31, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Maria Cristina Rodrigues Rangel
• Grantee: Leandro de Lima Coutinho
• Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 18/08107-2 - Targenting stemness as a strategy for treating triple-negative breast cancer, AP.JP
• Associated scholarship(s): 21/14642-0 - Mechanistic investigation of sulforaphane effects on the stemness phenotype of triple-negative breast cancer cells, BE.EP.MS

Abstract

In this master's project, we will investigate new approaches for the control and destruction of the undifferentiated cancer stem cell population (CSCs) in the treatment of the most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC). TNBC expresses neither estrogen (ER) and progesterone (PR) hormone receptors nor shows increased expression or amplification of epidermal growth factor 2 (HER2). In the absence of these markers, there are still no well-defined markers in the clinic that enable the use of target-directed therapies in TNBC. Thus, in this study we will establish complementary strategies to the treatment of TNBC that does not exclude the use of conventional therapies but enhance their action through the negative modulation of the population of CSCs, making resistant tumours more sensitive and responsive to treatments, and preventing their recurrence. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COUTINHO, LEANDRO DE LIMA; TORTELLI JUNIOR, THARCISIO CITRANGULO; RANGEL, MARIA CRISTINA. Sulforaphane: An emergent anti-cancer stem cell agent. FRONTIERS IN ONCOLOGY, v. 13, p. 10-pg., 2023-01-23. (18/08107-2, 21/14642-0, 20/04007-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

COUTINHO, Leandro de Lima. Effects of sulforaphane association to standard therapy for treating triple-negative breast cancer. 2022. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.