Abstract
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (Ph) resulting from the translocation between the long arms of chromosome 9 and 22 which causes the juxtaposition of the ABL and BCR genes. This phenomenon produces a BCR-ABL chimeric protein with increased constitutive tyrosine kinase activity, which enhances cell …