CV Lattes
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Birthplace: Brazil
graduation at Farmácia e Bioquímica - Farmácia Industrial from Universidade Federal de Santa Maria (1988), master's at Pharmacy from Universidade Federal de Santa Maria (1998) and doctorate at Pharmacy from Universidade de São Paulo (2003). Has experience in Pharmacy, acting on the following subjects: modelagem molecular, direct compression, planejamento de fármacos, physicochemical properties and factorial design. (Source: Lattes Curriculum)
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Non-small cell lung cancer (NSCLC) is the most common type of lung cancer accounting for about 85% of all lung cancer cases. Its 5-year survival rate remains at approximately 17%. Almost half of cases have locally advanced or widespread metastasis at diagnosis. In addition, it is therapeutically limited. Despite the successful use of small molecule inhibitors, a major problem reminiscent …
The proposal comprises the synthesis of a novel inhibitor of protein B-RAF V600E to treat melanoma (product) and the evaluation in vitro and in vivo of its pharmacological activity. Melanona represents only 4% of the types of skin cancer, but it is considered a highly aggressive disease due to its invasiveness and ability to develop metastasis. The World Health Organization has estimated …
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