CV Lattes
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ResearcherID
graduation at Farmácia e Bioquímica - Farmácia Industrial from Universidade Federal de Santa Maria (1988), master's at Pharmacy from Universidade Federal de Santa Maria (1998) and doctorate at Pharmacy from Universidade de São Paulo (2003). Has experience in Pharmacy, acting on the following subjects: modelagem molecular, direct compression, planejamento de fármacos, physicochemical properties and factorial design. (Source: Lattes Curriculum)
- Novel drug candidates to treat non-small cell lung cancer: lead optimization and development of CTP:phosphoethanolamine cytidylyltransferase inhibitors, AP.PIPE
Abstract
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer accounting for about 85% of all lung cancer cases. Its 5-year survival rate remains at approximately 17%. Almost half of cases have locally advanced or widespread metastasis at diagnosis. In addition, it is therapeutically limited. Despite the successful use of small molecule inhibitors, a major problem reminiscen...
- Rational design and development of new chemical entity as potentially BRAF V600E inhibitor to treat melanoma, AP.PIPE
Abstract
The proposal comprises the synthesis of a novel inhibitor of protein B-RAF V600E to treat melanoma (product) and the evaluation in vitro and in vivo of its pharmacological activity. Melanona represents only 4% of the types of skin cancer, but it is considered a highly aggressive disease due to its invasiveness and ability to develop metastasis. The World Health Organization has estimate...
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 4 / 1 | Completed scholarships in Brazil |
| 6 / 3 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 55 |
| Cit./Article | 4.6 |
| Data from Web of Science | |
SATO, ANA CLAUDIA; BOSCH, ROSEMARY VIOLA; ALVES WILL, SONIA ELISABETE; ALVAREZ-FLORES, MIRYAM PAOLA; GOLDFEDER, MAURICIO BARBUGIANI; MESQUITA PASQUALOTO, KERLY FERNANDA; VAZ GALVAO DA SILVA, BRBARA ATHAYDE; DE ANDRADE, SONIA APARECIDA; CHUDZINSKI-TAVASSI, ANA MARISA. Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 22, DEC 21 2016. Web of Science Citations: 1. (13/07467-1, 13/06892-0)
RANDO, DANIELA GONCALVES; GIAROLLA, JEANINE; MESQUITA PASQUALOTO, KERLY FERNANDA; FERREIRA, ELIZABETH IGNE. Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents. Brazilian Journal of Pharmaceutical Sciences, v. 46, n. 2, p. 311-321, APR-JUN 2010. Web of Science Citations: 3. (01/01192-3)
MESQUITA PASQUALOTO, KERLY FERNANDA; CARRIJO-CARVALHO, LINDA CHRISTIAN; CHUDZINSKI-TAVASSI, ANA MARISA. Rational development of novel leads from animal secretion based on coagulation and cell targets: 1. In silico analysis to explore a peptide derivative as lipocalins' signature. Toxicon, v. 69, n. SI, p. 200-210, JUL 2013. Web of Science Citations: 0.
GIAROLLA, JEANINE; MESQUITA PASQUALOTO, KERLY FERNANDA; FERREIRA, ELIZABETH I.. Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide. MOLECULAR DIVERSITY, v. 17, n. 4, p. 711-720, NOV 2013. Web of Science Citations: 8. (12/50034-6)
MESQUITA PASQUALOTO, KERLY FERNANDA; BALAN, ANDREA; BARRETO, SANDRA ALVES; SIMONS, SIMONE MICHAELA; CHUDZINSKI-TAVASSI, ANA MARISA. Structural Findings and Molecular Modeling Approach of a TFPI-Like Inhibitor. PROTEIN AND PEPTIDE LETTERS, v. 21, n. 5, p. 452-457, MAY 2014. Web of Science Citations: 6.
SANTOS, SORAYA DA SILVA; GIAROLLA, JEANINE; PASQUALOTO, KERLY F. M.; FERREIRA, ELIZABETH I.. In silico study to analyse the disassembly of quercetin-targeted dendrimers potentially leishmanicide. MOLECULAR SIMULATION, v. 41, n. 18, p. 1495-1508, DEC 12 2015. Web of Science Citations: 1. (12/50034-6)
XAVIER PRADO AMORIM, ADRIANE MICHELE; DE OLIVEIRA, URSULA CASTRO; FARIA, FERNANDA; MESQUITA PASQUALOTO, KERLY FEMANDA; JUNQUEIRA-DE-AZEVEDO, INACIO DE L. M.; CHUDZINSKI-TAVASSI, ANA MARISA. Transcripts involved in hemostasis: Exploring salivary complexes from Haementeria vizottoi leeches through transcriptomics, phylogenetic studies and structural features. Toxicon, v. 106, p. 20-29, NOV 2015. Web of Science Citations: 4. (11/16393-6)
SANTOS, SORAYA DA SILVA; GIAROLLA, JEANINE; PASQUALOTO, KERLY F. M.; FERREIRA, ELIZABETH I.. Molecular modelling as a tool for studying the disassembly of potentially leishmanicide-targeted dendrimer. MOLECULAR SIMULATION, v. 39, n. 11, p. 860-867, SEP 1 2013. Web of Science Citations: 3. (01/01192-3)
MORAIS, KATIA L. P.; MESQUITA PASQUALOTO, KERLY FERNANDA; FERNANDES PACHECO, MARIO THIEGO; BERRA, CAROLINA MARIA; ALVAREZ-FLORES, MIRYAM PAOLA; CHUDZINSKI-TAVASSI, ANA MARISA. Rational development of a novel TFPI-like inhibitor from Amblyomma cajennense tick. Toxin Reviews, v. 33, n. 1-2, SI, p. 48-52, MAR-JUN 2014. Web of Science Citations: 3. (11/05969-4, 10/07958-7)
CHUDZINSKI-TAVASSI, ANA MARISA; MORAIS, KATIA L. P.; FERNANDES PACHECO, MARIO THIEGO; MESQUITA PASQUALOTO, KERLY FERNANDA; DE SOUZA, JEAN GABRIEL. Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates. BIOMEDICINE & PHARMACOTHERAPY, v. 77, p. 14-19, FEB 2016. Web of Science Citations: 8. (13/07467-1, 11/05969-4, 10/07958-7, 98/14307-9)
GIAROLLA, JEANINE; PASQUALOTO, KERLY F. M.; RANDO, DANIELA G.; ZAIM, MARCIO H.; FERREIRA, ELIZABETH I.. Molecular modeling study on the disassembly of dendrimers designed as potential antichagasic and antileishmanial prodrugs. Journal of Molecular Modeling, v. 18, n. 5, p. 2257-2269, MAY 2012. Web of Science Citations: 8. (01/01192-3)
GIAROLLA, JEANINE; RANDO, DANIELA G.; PASQUALOTO, KERLY F. M.; ZAIM, MARCIO H.; FERREIRA, ELIZABETH I.. Molecular modeling as a promising tool to study dendrimer prodrugs delivery. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, v. 939, n. 1-3, p. 133-138, JAN 15 2010. Web of Science Citations: 10. (01/01192-3)