Abstract
Semaglutide is a GLP-1 analog widely used in obesity treatment. Besides its effects in reducing food intake, this drug has a direct effect on the metabolism of peripheral tissues. Activation of GLP1R in muscle cells increases intracellular AMPc levels, and our lab has already shown that the AMPc / protein kinase A (PKA) pathway has an anabolic role in muscular protein metabolism in rodent…