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Effects of maternal vitamin D deficiency on brown adipose tissue development and function in rat offspring

Grant number: 19/19993-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2019
Effective date (End): November 30, 2020
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Luiz Carlos Carvalho Navegantes
Grantee:Matheus Leonardo Moro
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:18/10089-2 - Neural, hormonal and nutritional control of autophagy, AP.TEM

Abstract

Vitamin D acts on differents body tissues and your deficiency increases the risk of development several chronic diseases, such as diabetes mellitus and obesity. Although there is evidence that vitamin D receptor (VDR) knockout animals show increased energy expenditure, the physiological importance of this hormone in brown adipose tissue (TAM), the main heat producing site in the body, is still little known. Therefore, this study aims to investigate the effects of maternal vitamin D deficiency, during pregnancy and lactation, on the development and function of rat offspring brown adipose tissue. With the use of Western blot and RT-PCR techniques, protein content and gene transcription of TAM differentiation (PRDM16 e CBEPA) and termogensis (UCP-1) markers will be investigated in animals exposed or not to cold. These results may contribute to a better undestanding of the role of the maternal vitamin D deficiency in the physiology of brown adipose tissue and the modulation of energy expenditure. (AU)