Abstract
The latest catalog of gene annotation and microRNAs (miRNAs), non-coding RNAs molecules involved in post-transcriptional gene regulation of chromosome 21, includes more than 223 coding genes and 30 miRNAs (HGNC, 2019). The contribution of these miRNAs to the Down syndrome (DS) phenotype is poorly investigated, but there is evidence some change in their expression could be related to manif…