Maiara Colombera has a degree in Biological Sciences (2020) from the State University of Campinas (UNICAMP). She is currently a Master's student in the Graduate Program in Functional and Molecular Biology at the State University of Campinas, in the area of human physiology, at the Nutrition and Cancer laboratory (FAPESP grant 2020 / 13222-5). She has a technical course in nursing (2012) from the Technical College of Limeira (COTIL / UNICAMP). From 2016 to 2017, she carried out a Scientific Initiation project in the area of Tissue Biology (PIBIC scholarship). From 2018 to 2020, she was a Scientific Initiation student at the Laboratory of Nutrition and Cancer (2019-PIBIC scholarship; 2020-FAPESP scholarship 2019 / 19779-4). She has expertise in the field of cell culture, molecular biology, physiology, cancer-cachexia, cardiac cachexia and nutrition. (Source: Lattes Curriculum)
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Cancer cachexia is a complex, systemic and multifactorial syndrome that cause several metabolic alterations. Skeletal muscle atrophy, the main consequence of cachexia, occurs due to protein imbalance. Protein degradation pathways can be activated by the Walker Factor, a cachexia-inducing protein, and by serum inflammatory cytokines, since inflammation is a common characteristic of cachexi…
The mechanism of protein catabolism in the skeletal muscle has been widely studied, especially that induced by a proteolysis-inducing factor (PIF; or even by Walker Factor), as occurred in human and experimental animal tumours. These studies include the cellular signaling processes and metabolic pathways involved mainly in the process of cachexia. In our previous studies we observed that …
Cancer cachexia is a complex, systemic, multifactorial syndrome that causes several metabolic alterations, affecting multiple organs, including the heart. Cardiac failures in patients with cancer cachexia have been widely reported, representing a severe problem limiting patient survival, but often underestimated and insufficiently studied. Cancer and heart diseases have been associated wi…
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