Postdoctoral researcher at the Institute for Genetics at the University of Cologne (Germany), investigating mono-ADP-ribosylation in cell lines. Holds a Bachelor's degree in Biomedical Sciences from the Bahia School of Medicine and Public Health (Brazil) and a Ph.D. in Biochemistry from the University of São Paulo (USP) - Brazil, with extensive experience in cellular and molecular biology and ADP-ribosylation. Throughout her academic career, she has received various grants and awards, including the Best Poster Award at the 68th Brazilian Congress of Genetics (2023). During her undergraduate studies, she was a scholar of the Educational Tutoring Program (PET Biomedicine EBMSP), a research intern at the Gonçalo Moniz Institute - FIOCRUZ BA, and president of the Academic League of Medical Genetics at the Federal University of Bahia (LAGeM UFBA).Areas of Interest: ADP-ribosylation and PARPs Cellular and molecular biology Teaching, outreach, and scientific mentoring (Source: Lattes Curriculum)
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Post-translational modifications, such as ubiquitination and ADP-ribosylation (the addition of ADP-ribose units catalyzed by enzymes of the PARP family), have a central role in cellular signaling cascades, such as DNA damage repair or the innate immune response. The PARP9/DTX3L heterodimer possesses both ADP-ribosyltransferase and E3 ubiquitin ligase activity and has been implicated in DN…
DNA damage signalling and repair, which are regulated by a variety of post-translational modifications including ubiquitination and ADP-ribosylation, prevent the genetic alterations that cause Cancer, neurodegeneration and aging. We have previously identified the ADP-ribosyl transferase PARP9 and the ubiquitin ligase DTX3L in an in vitro screen for factors that bind to a DNA damage-induce…
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CV Lattes
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