Abstract
Post-translational modifications, such as ubiquitination and ADP-ribosylation (the addition of ADP-ribose units catalyzed by enzymes of the PARP family), have a central role in cellular signaling cascades, such as DNA damage repair or the innate immune response. The PARP9/DTX3L heterodimer possesses both ADP-ribosyltransferase and E3 ubiquitin ligase activity and has been implicated in DN…