CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
PhD student in the Postgraduate Program in Systems Biology at the Institute of Biomedical Sciences of the University of São Paulo (ICB-USP) with the project entitled: "Development of a Biomimetic Microfluidic Device for In Vitro Bone Repair for Applications in Tissue Engineering" (2023-present).Graduated in Biomedical Sciences from the Institute of Biomedical Sciences of the University of São Paulo (ICB-USP) (2018-2023). He received a Scientific Initiation scholarship from FAPESP with project title: "The relationship between different sizes of spheroids in the genesis of central hypoxia and alteration of the multidifferentiation potential of human stem cells from dental pulp" (2020-2023) at the Biology Laboratory of Extracellular Matrix and Cellular Interaction (LabMec) and scholarship holder for an interchange with the project "Development of a dynamic microfluidic device for evaluating the angiogenic potential of osteogenic spheroids in vitro" (April 2023/May 2023) at INL, Braga, Portugal. He has a Technical Course in Pharmacy from the Professor Adhemar Batista Heméritas State Technical School (2015-2016). Volunteer biology teacher (2019-2023) and volunteer coordinator of Natural Sciences (2023) at Cursinho Popular Professora Leila Regina. (Source: Lattes Curriculum)
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During bone repair, the main immune cell involved in this process is the macrophage. Macrophages are responsible for the migration of other cell types, such as endothelial cells and resident stem cells, to the site of injury. The critical calvarial defect is a model to study bone repair and there is no in vitro platform for this type of evaluation. An alternative to mimic in vitro conditi…
The classic Bone Bioengineering approach (top-down) associates stem cells with biomaterials and signaling molecules. Recently, the bottom-up approach has been very interesting because it reproduces the cell-cell and cell-extracellular matrix interactions in the tissue environment. Thus, new three-dimensional (3D) cellular technologies such as spheroids, cell sheet and organoids have been …
The cultivation of spheroids and microfluidics are techniques used to create a microenvironment closer to the physiological one in vitro, recreating cell-cells, extracellular matrix-cells interaction and simulating hydrodynamic conditions. Some groups have used microfluidic devices to assess the chemotaxis produced by the spheroid secretome in relation to endothelial cell sprouting. It wa…
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