Abstract
Glioblastoma multiforme (GBM) are brain tumors considered incurable. Current treatmentwith the chemotherapy drug Temozolomide (TMZ) has a high rate of resistance and difficultyin crossing the blood-brain barrier (BBB). Drug delivery implants in the brain region are newpharmacological alternatives that avoid the need for BBB permeation. In a recent study, thecompound ingenol-3-dodecanoate …