Jennifer Ann Black in research grants and scholarships supported by FAPESP.
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Leishmania adaptability to different environmental conditions is often correlated to genome plasticity and general chromosome and gene copy number variations. The mechanisms by which DNA Replication Stress modulates genome plasticity in Leishmania are complex and involve multiple DNA Damage Repair pathways. Understanding these mechanisms will provide valuable insights into the biology of …
The genome of Leishmania is characterized by a remarkable plasticity that has been associated with the acquisition of drug resistance and with host adaptation. Here, we will explore if the parasite's signaling of replication 'stress' may underlie genome plasticity and diversity. The analysis of the ATR pathway, which is central to the detection and signaling DNA replication stress and dam…
| 2 / 2 | Completed scholarships in Brazil |
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