Abstract
Aldehyde dehydrogenase-2 (ALDH-2) is a mitochondrial enzyme responsible for eliminating toxic aldehydes from the peroxidation of unsaturated lipids present in the mitochondrial membrane. Initial studies carried out by our group, using a small activating molecule of ALDH-2, Alda-1, demonstrated that this molecule has a potent antinociceptive effect in an acute model of inflammatory hyperno…