Head of Drug Discovery at the Brazilian Biosciences National Laboratory (LNBio/CNPEMCampinas, SP). Graduated in Biological Sciences (2003) with Master in Biotechnology (2006) from the Federal University of Santa Catarina, PhD in Sciences from the University of Sao Paulo (2010) and pos-doctoral research at the Institute of Chemistry, UNICAMP (2010-2013), at the University of California at San Diego (2012) and at the University of Nottingham (2015-2016). Her main scientific interests is are on the discovery of novel bioactive natural products, protein allosteric modulators and their development into new drugs. Develops new tools for the discovery, characterisation and production of new natural products and customised derivatives for drug discovery projects with the Academia and Industry. (Source: Lattes Curriculum)
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The microbial communities present in the ocean represent a large genetic reservoir that is still little explored. The marine environment has several habitats with unique and often extreme conditions, which allow the selection of microorganisms producing differentiated secondary metabolites (natural products). These are encoded by biosynthetic genes and have great potential for the discove…
G protein coupled receptors (GPCRs) are transmembrane proteins with essential roles in physiology and disease. They enable cells to respond to stimuli by ligands, such as peptides, neurotransmitters, lipids, hormones, carbohydrates, glycoproteins, ions, photons and odorants, and are the targets of many drugs used in the clinic. The signalling pathways and protein structures associated wit…
The proteasome complex is a validated target against cancer and two drugs, carfilzomib e bortezomib, are currently available in the market. However, there still some problems, such as resistance, toxicity and distribution, found in these inhibitors. Therefore, the discovery and development of next generation proteasome inhibitors are necessary. In this project we aim to discover new chemi…
Cancer is the second non-accidental cause of death in Brazil, where the annual governmental expenses with this pathology are around 1 billion Reais. In many cases, anticancer treatment and therapies fail, being of extremely important the development of new therapies or the improvement of the existent ones. The design of activity modulators of tumor overexpressed proteins is one of the mai…
Tranthyretin amyloid fibril deposition is associated with chronic-degenerative diseases, such as SSA (senile systemic amyloidosis), FAP (familial amyloid polyneuropathy) and FAC (amilial amyloid cardimyopathy). Recently, the effect of low molecular weight chemical compounds on the binding and stabilization capacity of TTR tetramer and consequent amyloid fibril formation inhibition was eva…
Two main activities, related to the original aims of the post doctoral research project, were outlined: the search for new classes of phosphatase inhibitors and the search for new biological targets against cancer. It is intended to include the 20S subunit of the proteasome as a new biological target in trials with the organic compounds already synthesized in the context of the Thematic P…
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 4 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 9 / 7 | All research grants and scholarships |
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CV Lattes
ORCID