CV Lattes
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Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Principal Investigator and head of research at LNBio-CNPEM (Campinas, SP). Graduated in Biological Sciences (2003) from the Federal University of Santa Catarina , Master in Biotechnology (2006) from the Federal University of Santa Catarina, PhD in Sciences from the University of Sao Paulo (2010) and pos-doctoral research at the Institute of Chemistry, UNICAMP (2010-2013), at the University of California at San Diego (2012) and at the University of Nottingham (2016). Is an independent researcher at the Brazilian National Laboratory for Biosciences. Has experience in the area of Medicinal Chemistry, Biochemistry and Biophysics, with emphasis on structural biology (protein crystallography), thermodynamics (microcalorimetry) and enzyme kinetics. The main research interest is on the discovery of new bioactive natural products, mainly those of marine and microbial origin. Develops tools for the structural and biochemical characterisation of proteins with pharmaceutical interest and their interaction with natural products. (Source: Lattes Curriculum)
The microbial communities present in the ocean represent a large genetic reservoir that is still little explored. The marine environment has several habitats with unique and often extreme conditions, which allow the selection of microorganisms producing differentiated secondary metabolites (natural products). These are encoded by biosynthetic genes and have great potential for the discove…
G protein coupled receptors (GPCRs) are transmembrane proteins with essential roles in physiology and disease. They enable cells to respond to stimuli by ligands, such as peptides, neurotransmitters, lipids, hormones, carbohydrates, glycoproteins, ions, photons and odorants, and are the targets of many drugs used in the clinic. The signalling pathways and protein structures associated wit…
The proteasome complex is a validated target against cancer and two drugs, carfilzomib e bortezomib, are currently available in the market. However, there still some problems, such as resistance, toxicity and distribution, found in these inhibitors. Therefore, the discovery and development of next generation proteasome inhibitors are necessary. In this project we aim to discover new chemi…
Cancer is the second non-accidental cause of death in Brazil, where the annual governmental expenses with this pathology are around 1 billion Reais. In many cases, anticancer treatment and therapies fail, being of extremely important the development of new therapies or the improvement of the existent ones. The design of activity modulators of tumor overexpressed proteins is one of the mai…
Tranthyretin amyloid fibril deposition is associated with chronic-degenerative diseases, such as SSA (senile systemic amyloidosis), FAP (familial amyloid polyneuropathy) and FAC (amilial amyloid cardimyopathy). Recently, the effect of low molecular weight chemical compounds on the binding and stabilization capacity of TTR tetramer and consequent amyloid fibril formation inhibition was eva…
Two main activities, related to the original aims of the post doctoral research project, were outlined: the search for new classes of phosphatase inhibitors and the search for new biological targets against cancer. It is intended to include the 20S subunit of the proteasome as a new biological target in trials with the organic compounds already synthesized in the context of the Thematic P…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 4 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 9 / 7 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 8 |
| Citations | 52 |
| Cit./Article | 6.5 |
| Data from Web of Science | |
DE FELICIO, RAFAEL; BALLONE, PATRICIA; BAZZANO, CRISTINA FREITAS; ALVES, LUIZ F. G.; SIGRIST, RENATA; INFANTE, GINA POLO; NIERO, HENRIQUE; RODRIGUES-COSTA, FERNANDA; FERNANDES, ARTHUR ZANETTI NUNES; TONON, LUCIANE A. C.; et al. Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions. METABOLITES, v. 11, n. 2, FEB 2021. Web of Science Citations: 0. (14/10753-9, 17/12436-9, 15/19906-5)
WAECHTER, FERNANDA; DA SILVA, GLORIA N. S.; WILLIG, JULIA B.; DE OLIVEIRA, CRISTIANE B.; VIEIRA, BRUNA D.; TRIVELLA, DANIELA B. B.; ZIMMER, ALINE R.; BUFFON, ANDREIA; PILGER, DIOGO A.; GNOATTO, SIMONE C. B.. Design, Synthesis and Biological Evaluation of Betulinic Acid Derivatives as New Antitumor Agents for Leukemia. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 17, n. 13, p. 1777-1785, 2017. Web of Science Citations: 3. (14/10753-9)
TRIVELLA, DANIELA B. B.; PEREIRA, ALBAN R.; STEIN, MARTIN L.; KASAI, YUSUKE; BYRUM, TARA; VALERIOTE, FREDERICK A.; TANTILLO, DEAN J.; GROLL, MICHAEL; GERWICK, WILLIAM H.; MOORE, BRADLEY S.. Enzyme Inhibition by Hydroamination: Design and Mechanism of a Hybrid Carmaphycin-Syringolin Enone Proteasome Inhibitor. CHEMISTRY & BIOLOGY, v. 21, n. 6, p. 782-791, JUN 19 2014. Web of Science Citations: 12. (11/21358-5)
TRIVELLA, DANIELA B. B.; DOS REIS, CAIO V.; LIMA, LUIS MAURICIO T. R.; FOGUEL, DEBORA; POLIKARPOV, IGOR. Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. Journal of Structural Biology, v. 180, n. 1, p. 143-153, OCT 2012. Web of Science Citations: 24. (09/54035-4, 06/01708-3)
FONSECA, EMANUELLA M. B.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; DIAS, MARIANA P.; BAZZO, NATALIA L.; MANDAPATI, KISHORE R.; DE OLIVEIRA, FABIO L.; FERREIRA-HALDER, CARMEN V.; PILLI, RONALDO A.; MIRANDA, PAULO C. M. L.; et al. Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorganic & Medicinal Chemistry, v. 23, n. 15, p. 4462-4471, AUG 1 2015. Web of Science Citations: 4. (09/51602-5, 10/17544-5, 11/15792-4, 11/03054-9)
TONETO NOVAES, LUIZ FERNANDO; AVILA, CAROLINA MARTINS; PELIZZARO-ROCHA, KARIN JULIANE; VENDRAMINI-COSTA, DEBORA BARBOSA; DIAS, MARINA PEREIRA; BARBOSA TRIVELLA, DANIELA BARRETO; DE CARVALHO, JOAO ERNESTO; FERREIRA-HALDER, CARMEN VERISSIMA; PILLI, RONALDO ALOISE. (-)-Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies. CHEMMEDCHEM, v. 10, n. 10, p. 1687-1699, OCT 2015. Web of Science Citations: 5. (10/17544-5, 13/08896-3, 12/24385-6, 10/08673-6, 09/51602-5, 12/09254-2)
CARNEIRO, VANIA M. T.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; BERALDO, VIVIANE L.; DIAS, MARIANA P.; SOBREIRA, TIAGO J. P.; APARICIO, RICARDO; PILLI, RONALDO A.. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 97, p. 42-54, JUN 5 2015. Web of Science Citations: 4. (09/51602-5, 13/07607-8, 10/17544-5, 11/00457-5)
GRIGOLETTO, DIANA F.; TRIVELLA, DANIELA B. B.; TEMPONE, ANDRE G.; RODRIGUES, ANDRE; CORREIA, ANA MARIA L.; LIRA, SIMONE P.. Antifungal compounds with anticancer potential from Trichoderma sp. P8BDA1F1, an endophytic fungus from Begonia venosa. Brazilian Journal of Microbiology, v. 51, n. 3, APR 2020. Web of Science Citations: 0. (14/10753-9, 14/15760-3, 13/50228-8, 14/12021-5)
(References retrieved automatically from State of São Paulo Research Institutions)
TRIVELLA, Daniela Barretto Barbosa. Estudos bioquímicos e estruturais com o complexo proteassomo : busca de novos inibidores e mecanismos de resistência e inibição deste alvo contra o câncer. Dissertação (Mestrado) - Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). (14/10753-9)
TRIVELLA, Daniela Barretto Barbosa. Bases moleculares e estruturais do reconhecimento de ligantes pela proteína transtirretina humana. Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (06/01708-3)