CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Biomedical Scientist from Universidade Feevale (2010), Master's in Genetics and Molecular Biology from Universidade Federal do Rio Grande do Sul (2013), and Ph.D. in Sciences (Genetics and Molecular Biology) also from Universidade Federal do Rio Grande do Sul (2017). Post-Doctoral Fellow in Psychiatry and Behavioral Sciences at Universidade Federal do Rio Grande do Sul (from early 2017 to early 2020). Currently, he is a Tenured Assistant Professor in the Department of Physiology and Biophysics at the Institute of Biomedical Sciences of Universidade de São Paulo and a supervisor in the Graduate Program in Functional and Molecular Biology at Universidade de São Paulo, leading a research line in Physiological Genomics of Mental Health (https://ww3.icb.usp.br/rovaris/). Received the 2017 Young Geneticist Award, the highest award granted by the Brazilian Society of Genetics to a recent Ph.D. Also received the 2018 Brazilian Thesis Award in his field. Member of IMpACT (International Multi-centre persistent ADHD Collaboration) and collaborator of the PGC (Psychiatric Genomics Consortium) ADHD working group. Coordinator of the ADHD working group of LAGC (Latin American Genomics Consortium). Principal investigator of CONNECT-ADHD (comprehensive exploration of the CONNECtion between ADHD and educational attainment in contrasting environments), a project participating in the Ancestral Populations Network of the National Institute of Mental Health (NIMH-NIH). Awarded the 2020 Brain Behavior Research Foundation Young Investigator Grant and the FAPESP Young Researcher Grant (2022). Leads an R01 funded by the National NIMH-NIH (2022). (Source: Lattes Curriculum)
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Countries with high social inequalities, such as Brazil, present a "potential context" for assessing the impact of exposome on mental health. This study will examine if the social factors (poverty and urban and domestic violence) play a differential role in the genomic, epigenomic, and gut microbial modulation involved in mental disorders with a high heritability, such as attention defici…
Iron plays a crucial role in the development and proper function of the brain, especially in cognitive functions such as attention and memory. Evidence suggests that its deficiency during development is associated with neuropsychiatric disorders, including Attention Deficit Hyperactivity Disorder (ADHD). Genome-wide association studies (GWAS) are important tools for identifying genetic va…
Attention deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD) are strongly correlated both at the epidemiological, clinical, and biological levels. ADHD exhibits one of the highest heritabilities in psychiatry, meaning that the innate biological component behind the disorder is extremely relevant to its manifestation. Conversely, MDD is a disorder with moderate herit…
Among neurodevelopmental conditions, attention deficit hyperactivity disorder (ADHD) is one of the most common, affecting 3 to 5% of the world population. ADHD is defined as a complex trait with multifactorial origins, meaning it is influenced by both genetic and environmental factors. There is a high association between the presence of this disorder and other neuropsychiatric phenotypes,…
Although the total heritability of ADHD is estimated at H 80%, the proportion of phenotypic variability explained by common genome variability is only 14% (SNP heritability). This demonstrates that other biological components play an important role in ADHD. Epigenetic mechanisms, which operate at the intersection of individuals' genomic and environmental contexts, are important candidates…
The great performance of polygenic risk scores (PRS) has already been demonstrated for some physiological variables, such as blood pressure. In the case of mental disorders, several studies have also replicated, in several target samples, the effects of PRSs for schizophrenia, major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD), among others. However, most dis…
(Only some records are available in English at this moment)
Psychosocial factors can impact epigenetic mechanisms, resulting in changes in gene expression. Disorders such as Major Depressive Disorder (MDD) and Attention Deficit Hyperactivity Disorder (ADHD) are influenced by both genetic and environmental factors. Recently, the relationship between these disorders and epigenetic changes has been explored, although the results are still preliminary…
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