Abstract
Background: The first-line treatment for Prostate Cancer (PCa) patients is androgen deprivation therapy (ADT). Immunotherapy usually fails because PCa is an immunologically cold tumor. In 50% of PCa ETS gene is highly expressed because of fusion with the androgen-responsive TMPRSS2 gene. We have shown that PTEN loss may be involved in immune evasion in PCa. ETS overexpression induces di…