CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Biológicas e da Saúde (CCBS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Has experience in Psychology, focusing on Experimental Psychology (Source: Lattes Curriculum)
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With the increase in life expectancy, cases of neurodegenerative diseases such as Alzheimer's disease (AD), have also risen. Characterized by a progressive neurodegeneration and cognitive impairment, AD has a major pathological hallmark: the hyperphosphorylated tau protein, which aggregates intracellularly into neurofibrillary tangles, and the beta-amyloid peptide (A²), which forms senile…
Alzheimer's Disease (AD) is the most common cause of dementia in elders. Previous studies have shown as a possible mediator of the neurodegeneration an early-onset deficit in the metabolism of brain glucose and in the insulin signaling pathway. As a consequence, oxidative stress, neuroinflammation, activation of astrocytes and microglia, apoptosis, increase in the production of beta amylo…
A disintegrin and metalloprotease 10 (ADAM10), a transmembrane protein, has been investigated as an Alzheimer's disease (AD) blood-based biomarker. Under physiological conditions, it is the major constitutive ±-secretase responsible for the non-amyloidogenic cleavage of amyloid precursor protein (APP), preventing the generation of the amyloid beta peptide (AB). In AD, however, there is a …
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