Currently in her eighth semester of the Bachelor's degree in Fundamental Sciences for Health at the Institute of Biomedical Sciences of the University of São Paulo (ICB/USP). Since 2022, she has been pursuing a full-time undergraduate research program with a FAPESP grant at the Center of Antibody Development at the Butantan Institute, focusing on immune checkpoint inhibitors for antitumor immunotherapy. She completed short-term internships in three laboratories of the Immunology Department at ICB/USP and served as a volunteer tutor for the Immunology course at the same institute. She studied Biotechnology at USP (2021) and completed a technical course in Pharmacy at the Praia Grande State Technical School (2019). (Source: Lattes Curriculum)
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Despite significant advances in research, cancer still represents a threat to global health. The chronicity of this disease and constant antigenic stimulation leads to the differentiation of CD8+ T cells into populations with altered effector functions, a unique epigenetic profile, and high levels of expression of multiple inhibitory receptors. Such negative regulatory receptors have the …
Immune checkpoints are negative regulatory receptors expressed on immune cells. Under normal physiological conditions, its function is to act as a brake on the immune system, maintaining self-tolerance and preventing immunopathologies. However, these molecules also participate in immune escape mechanisms, causing dysfunction in T cell populations in a variety of diseases, including cancer…
Despite advances in research, skin cancer remains the most common type of tumor in Brazil. Nivolumab, an anti-PD-1 monoclonal antibody, has shown success in the treatment of melanoma. This antibody blocks the immune checkpoint PD-1, a molecular receptor expressed by immune cells that when interacts with their ligands leads these cells to an exhaustion state, in which they present altered …
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CV Lattes
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