Currently, the author is a doctoral student and recipient of a FAPESP scholarship within the scope of the Postgraduate Program in Oncology at the PIOXII Foundation - Barretos Cancer Hospital. He completed his master's degree in Hematology and Oncology at the Federal University of São Paulo (UNIFESP) in 2023, during which he received financial support from FAPESP. His academic background includes a bachelor's degree in Biological Sciences from the Federal University of Uberlândia (UFU) in 2019, where he played a role as a CNPq scholarship holder during Scientific Initiation in the field of Mutagenesis. He served as a Monitor for the Human Anatomy Discipline and was a Teacher in the VIVABIOLOGIA Project. During undergraduate studies, he undertook an Internship at the DNA Repair Laboratory at the Institute of Biomedical Sciences (ICB), Department of Microbiology, at the University of São Paulo (USP). (Source: Lattes Curriculum)
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The RAS gene family, comprising KRAS, NRAS, and HRAS, is the most frequently mutated in cancers, with KRAS mutations accounting for approximately 75% of these cases. These mutations play a crucial role in the development of lung, colorectal, and pancreatic cancers, all of which have high mortality rates, prompting a decades-long search for effective KRAS protein inhibitors. However, due t…
The UVC light (200-280 nm) is absorbed by the DNA molecule generating mainly two types of lesions: cyclobutane pyrimidine dyes and photoproducts (6-4)-pyrimidine-pyrimidine, which distort the DNA tape. This damage, when not removed by DNA repair systems, can lead to the stop and, consequently, the collapse of the DNA replication fork. However, this phenomenon is avoided thanks to the pres…
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