Abstract
PTPMT1 is a mitochondrial protein tyrosine phosphatase and is involved in ATP synthesis and insulin secretion in pancreatic beta cells and in cardiolipin biosynthesis. PTPMT1 was the first protein phosphatase identified in mitochondria. Although PTPMT1 has been described as a PLIP (PTEN like protein), because it has a sequence in the PTP loop similar to that of PTEN, and because it has a …